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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in grown-ups with a body mass index (BMI) in excess of 27, given that they also experience weight-related health problems such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder and as an aid to stop smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that includes a reduced-calorie exercise and dieting, Contrave provides another treatment option for chronic weight-loss for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular physical exercise. Results from a clinical study that enrolled patients without diabetes indicated that patients had an average weight loss of four years old.1% rather than participants who have been given placebos) throughout a 12- month period, while a different study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at twelve months.

Using two separate drugs to shed weight can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it you need to err to the side of caution and allow FDA do its job and demand some investigation be done so your public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say almost anything to keep people on their own medications.

Researchers discovered that participants taking this drug to get a year, dropped a few pounds within 4 weeks and have kept the extra weight off throughout the 56 weeks with the study. Contrave is often a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs that are made up of several active ingredient, which might make them more effective and safer.

Combo-pilling could be the newest fad or in addition to this the newest into the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular may be the fact that since right now there aren't long term prescription weight loss supplements that have been licensed by the FDA apart from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be authorized by the FDA.

Seizures certainly are a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug also can raise blood pressure levels and heartrate, and really should not be used in people with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure level and heartbeat and must 't be used in patients with uncontrolled high blood pressure levels, as well as by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients having a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients on the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.


New UCLA study on smokers with mental, drug, and alcohol problems